GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THYM | cis | rs454422 | 1 | rs454422 | chr20:5943693 | MCM8 | chr20:5931298-5975829:+ | -0.22 | -4.5 | 1.96E-5 | HIV-1 viral setpoint |
| THYM | cis | rs2275426 | 1 | rs4545281 | chr1:46360054 | CCDC163P | chr1:45960581-45965646:- | -0.48 | -5.85 | 6.88E-8 | Body mass index |
| THYM | cis | rs12780845 | 1 | rs45472399 | chr10:17209967 | CUBN | chr10:16865966-17171816:- | 0.31 | 4.7 | 8.68E-6 | Homocysteine levels |
| THYM | cis | rs2243480 | 1 | rs4548056 | chr7:65298873 | CCT6P1 | chr7:65216092-65228661:+ | 0.64 | 4.78 | 6.3E-6 | Diabetic kidney disease |
| THYM | cis | rs4372836 | 1 | rs4549034 | chr2:28972579 | TRMT61B | chr2:29072690-29093175:- | -0.5 | -4.16 | 6.98E-5 | Body mass index |
| THYM | cis | rs11723261 | 1 | rs4549329 | chr4:239785 | ZNF718 | chr4:53272-156488:+ | 0.53 | 5.92 | 5.01E-8 | Immune response to smallpox vaccine (IL-6) |
| THYM | cis | rs7552404 | 1 | rs4559448 | chr1:76203456 | ACADM | chr1:76190043-76229353:+ | 0.3 | 4.24 | 5.21E-5 | Blood metabolite levels;Acylcarnitine levels |
| THYM | cis | rs6477998 | 1 | rs4560868 | chr9:115985499 | CDC26 | chr9:116029290-116037869:- | 0.37 | 6.02 | 3.22E-8 | Hematology traits |
| THYM | cis | rs12780845 | 1 | rs45615636 | chr10:17210591 | CUBN | chr10:16865966-17171816:- | 0.3 | 4.68 | 9.61E-6 | Homocysteine levels |
| THYM | cis | rs10935120 | 1 | rs4572812 | chr3:134291177 | ANAPC13 | chr3:134196547-134204865:- | -0.59 | -8.13 | 1.58E-12 | Height |
| THYM | cis | rs10935120 | 1 | rs4572812 | chr3:134291177 | CEP63 | chr3:134204575-134293852:+ | -0.41 | -5.87 | 6.33E-8 | Height |
| THYM | cis | rs9902453 | 1 | rs4575590 | chr17:28361969 | EFCAB5 | chr17:28256874-28435469:+ | -0.31 | -4.25 | 5.04E-5 | Coffee consumption (cups per day) |
| THYM | cis | rs9902453 | 1 | rs4581755 | chr17:28427898 | EFCAB5 | chr17:28256874-28435469:+ | 0.31 | 4.23 | 5.4E-5 | Coffee consumption (cups per day) |
| THYM | cis | rs11723261 | 1 | rs4582105 | chr4:246342 | ZNF718 | chr4:53272-156488:+ | 0.68 | 7.3 | 8.88E-11 | Immune response to smallpox vaccine (IL-6) |
| THYM | cis | rs2243480 | 1 | rs458291 | chr7:65520479 | CCT6P1 | chr7:65216092-65228661:+ | 0.67 | 5.68 | 1.48E-7 | Diabetic kidney disease |